![]() These values, which vary by age and sex, include: DRI is the general term for a set of reference values used for planning and assessing nutrient intakes of healthy people. Intake recommendations for chromium and other nutrients are provided in the Dietary Reference Intakes (DRIs) developed by an expert committee of the FNB at the National Academies of Sciences, Engineering, and Medicine. However, no validated methods for determining chromium status and no clinically defined chromium deficiency state exist. Hair levels might reflect past chromium intakes, and some studies have measured chromium levels in hair, sweat, serum, and toenails. However, because these levels are closely related to recent chromium intakes, they are not good indicators of chromium body stores. Urinary chromium levels are therefore a good indicator of chromium absorption. Ĭhromium is excreted mainly in the urine. Chromium accumulates mainly in the liver, spleen, soft tissue, and bone. In the blood, most chromium is bound to plasma proteins, particularly transferrin, and only about 5% is unbound. However, in 2014, the European Food Safety Authority Panel on Dietetic Products, Nutrition and Allergies concluded that no convincing evidence shows that chromium is an essential nutrient and, therefore, setting chromium intake recommendations would be inappropriate. The FNB has not evaluated chromium since 2001. However, recent research has suggested that although chromium might have benefits at pharmacologic amounts (e.g., in the hundreds of mcg), it is not an essential mineral because an absence or deficiency of chromium does not produce abnormalities that can be reversed with the addition of chromium (see the Chromium Deficiency section below). In 2001, the Food and Nutrition Board (FNB) of the National Academies of Sciences, Engineering, and Medicine considered chromium to be an essential nutrient based on its effects on insulin action. Chromium might also have antioxidant effects. Although the precise mechanism for this activity has not been identified, scientists have proposed that chromium binds to an oligopeptide to form chromodulin, a low-molecular-weight, chromium-binding substance that binds to and activates the insulin receptor to promote insulin action. This fact sheet focuses entirely on trivalent chromium.Ĭhromium might play a role in carbohydrate, lipid, and protein metabolism by potentiating insulin action. ![]() ![]() Chromium also exists as hexavalent (+6) chromium, a toxic by-product of stainless steel and other manufacturing processes. IntroductionĬhromium, as trivalent (+3) chromium, is a trace element that is naturally present in many foods and available as a dietary supplement. ![]() For a general overview of Chromium, see our consumer fact sheet on Chromium. It should not be construed as offering an approval for any specific use scenario.This is a fact sheet intended for health professionals. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. Material tested:Dermatril? (KCL 740 / Aldrich Z677272, Size M)ĭata source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail test method: EN374 Minimum layer thickness: 0,11 mm Break through time: 480 min ![]() The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. ![]()
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